(8S,9aS)-8-(5-bromo-6-((S)-1-methoxyethyl)pyridin-3-yl)octahydropyrido[2,1-c][1,4]oxazine

(S)-1-(5-bromo-6-(1-methoxyethyl)pyridin-3-yl)-N-methylcyclopropanamine hydrochloride

(S)-5-(5-bromo-6-(1-methoxyethyl)pyridin-3-yl)-2-(piperidin-1-ylmethyl)pyrimidine

(S)-tert-butyl 4-(4-(5-bromo-6-(1-methoxyethyl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

(7R,14R)-1-(difluoromethoxy)-6-((1-fluorocyclopropyl)methyl)-11-(2-((1s,3S)-3-(fluoromethyl)-1-hydroxy-3-methylcyclobutyl)pyrimidin-5-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(1R,3r)-3-(5-((7R,14R)-1-(difluoromethoxy)-6-ethyl-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)pyrimidin-2-yl)-1-(fluoromethyl)-3-hydroxycyclobutanecarbonitrile

(7R,14R)-11-(2-(1-aminocyclobutyl)pyrimidin-5-yl)-1-(difluoromethoxy)-6-((1-(fluoromethyl)cyclopropyl)methyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(1R,3r)-3-(5-((7R,14R)-1-(difluoromethoxy)-6-((2-fluorocyclopropyl)methyl)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)pyrimidin-2-yl)-1-(fluoromethyl)-3-hydroxycyclobutanecarbonitrile

(1S,3s)-3-(5-((7R,14R)-1-(difluoromethoxy)-6-((3-methoxycyclobutyl)methyl)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)pyrimidin-2-yl)-3-hydroxy-1-methylcyclobutanecarbonitrile

(7R,14R)-1-(difluoromethoxy)-11-(6-((dimethylphosphoryl)methoxy)pyridin-3-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(S)-5-((1-(azetidin-1-yl)cyclopropyl)ethynyl)-3-bromo-2-(1-methoxyethyl)pyridine

3-bromo-5-iodo-2-(1-methoxyethyl)pyridine

(S)-tert-butyl 4-(5-(5-bromo-6-(1-methoxyethyl)pyridin-3-yl)pyrimidin-2-yl)piperazine-1-carboxylate

(S)-3-bromo-5-(2-(4-(((tert-butoxycarbonyl)amino)methyl)-4-cyanopiperidin-1-yl)ethoxy)-2-(1-methoxyethyl)pyridine 1-oxide

(7R,14R)-1-(difluoromethoxy)-11-(2-((1r,3R)-3-(fluoromethyl)-1-hydroxy-3-methylcyclobutyl)pyrimidin-5-yl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(7R,14R)-11-(2-((R,E)-1-amino-3-(fluoromethylene)cyclopentyl)pyrimidin-5-yl)-1-(difluoromethoxy)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(7R,14R)-1-(difluoromethoxy)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(1R,3r)-3-(5-((7R,14R)-1-(difluoromethoxy)-6-(((1s,3S)-3-fluorocyclobutyl)methyl)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)pyrimidin-2-yl)-1-(fluoromethyl)-3-hydroxycyclobutanecarbonitrile

(7R,14R)-11-[(7S)-7-amino-6,7-dihydro-7-(trifluoromethyl)-5H-cyclopenta[b]pyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-[(7R)-7-amino-6,7-dihydro-7-(hydroxymethyl)-5H-cyclopenta[b]pyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one